2018年3月16日

T1DM妊娠有希望进行闭环胰岛素输送

(HealthDay)-根据3月13日在线发表的一项研究,对于1型糖尿病孕妇,与传感器增强泵(SAP)治疗相比,闭环系统与可比的血糖控制和低血糖明显更少。 糖尿病护理.

英国剑桥大学的佐伊·斯图尔特(Zoe A.Stewart)和同事招募了16名 开放标签的随机试验。参与者完成了28天的闭环治疗,SAP胰岛素的输送被清除期隔开;产后最多六个星期,参与者可以继续使用闭环系统。

研究人员发现,时间比例与 within target was comparable for the closed-loop and SAP insulin delivery periods (62.3 versus 60.1 percent). There was also no difference in the mean glucose (131.4 versus 131.4 mg/dL) and time spent hyperglycemic >140 mg/dL (36.6 versus 36.1 percent). Significantly fewer hypoglycemic episodes (median, 8.0 versus 12.5), and less time at <63 mg/dL (1.6 versus 2.7 percent) occurred during closed-loop; the rates of hypoglycemia <50 mg/dL (0.24 versus 0.47 percent) and low blood glucose index (1.0 versus 1.4) were significantly lower. During closed-loop therapy there was significantly less nocturnal hypoglycemia (1.1 versus 2.7 percent).

这组作者写道:“现在表明,进行更大,更长时间的多中心试验可以确定T1D妊娠中闭环胰岛素递送的临床疗效以及对新生儿结局的影响。”

几位作者透露了与制药和医疗器械行业的财务关系;几位作者报告了相关专利和专利申请。

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